The Rangers' last postseason appearance before 2010 was in 1999.Heading into 2010, the Rangers were plagued with off-field issues.For the second consecutive year, Series games were scheduled for earlier start times in hope of attracting younger viewers.First pitch was just before San Francisco landmarks, such as Coit Tower, the Ferry Building, and San Francisco City Hall, were illuminated with orange lighting at night during the postseason.Despite being 10 games under .500, the Rangers were leading the American League West division on , 1994, when the 1994–95 Major League Baseball strike began and the remainder of the season was cancelled.They went on to win three division titles in 1996, 1998, and 1999, but were eliminated by the New York Yankees in the ALDS each time, having only won one game out of all three series combined.
However, the next three games were all blowouts, as the Rangers took a 3–1 series lead.
The Rangers also traded two minor leaguers to the Florida Marlins in exchange for Jorge Cantú, and Joaquín Árias to the New York Mets in exchange for Jeff Francoeur.
The Rangers spent most of the season in first place in the American League West, with both the Los Angeles Angels of Anaheim and Seattle Mariners failing to live up to expectations by ESPN critics.
An exclusive VIP party was held on the eve of the World Series at the California Academy of Sciences (in Golden Gate Park); most media were not allowed near the event.
San Francisco mayor Gavin Newsom made a friendly wager with Arlington mayor Robert Cluck, agreeing that "the losing city's mayor will travel to the winning city and join the winning city's mayor in a day of support for local youth and community service initiatives, with both mayors wearing the jersey of the World Series Champion team." With three games slated in Arlington, this marked the 5th time the same city hosted both a World Series game and the upcoming Super Bowl (Los Angeles 1966–67, Minneapolis 1991–92, Atlanta 1999–2000, Tampa 2008–09).